Pufferfishes contain tetrodotoxin, among the most powerful natural toxins known. Cooking does not neutralise it and 2 milligrammes can kill a human. Tetradotoxin attacks nerves that are found in many animals including the pufferfish itself. How is it that the toxins in a pufferfish that make it deadly doesn't kill the pufferfish itself?
In particular as the toxins are not made by the fish. Evidence suggests the fish gets it from tetrodotoxin-producing bacteria that is found in its food. For instance, pufferfishes artificially raised in filtered, bacteria-free water, are nontoxic.
So, why aren’t pufferfishes dead?